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Index > Protein center > GLS2(Gene name) > Human
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  • GLS2 (Gene name),
  • Glutaminase liver isoform, mitochondrial (Protein name ),  GLSL_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    GLS2(GA);
    Protein name:
    Glutaminase liver isoform, mitochondrial(GLS);
    Alternative:
    L-glutamine amidohydrolase;L-glutaminase;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with the PDZ domain of the syntrophin SNTA1. Interacts with the PDZ domain of TAX1BP3.
    Function:
    Plays an important role in the regulation of glutamine catabolism. Promotes mitochondrial respiration and increases ATP generation in cells by catalyzing the synthesis of glutamate and alpha-ketoglutarate. Increases cellular anti-oxidant function via NADH and glutathione production. May play a role in preventing tumor proliferation.
    Subcellular Location:
    Mitochondrion
    Protein Attributes:
    Sequence length:
    602
    Sequence:
    50:
    MRSMKALQKA | LSRAGSHCGR | GGWGHPSRSP | LLGGGVRHHL | SEAAAQGRET | 
    100:
    PHSHQPQHQD | HDSSESGMLS | RLGDLLFYTI | AEGQERIPIH | KFTTALKATG | 
    150:
    LQTSDPRLRD | CMSEMHRVVQ | ESSSGGLLDR | DLFRKCVSSN | IVLLTQAFRK | 
    200:
    KFVIPDFEEF | TGHVDRIFED | VKELTGGKVA | AYIPQLAKSN | PDLWGVSLCT | 
    250:
    VDGQRHSVGH | TKIPFCLQSC | VKPLTYAISI | STLGTDYVHK | FVGKEPSGLR | 
    300:
    YNKLSLNEEG | IPHNPMVNAG | AIVVSSLIKM | DCNKAEKFDF | VLQYLNKMAG | 
    350:
    NEYMGFSNAT | FQSEKETGDR | NYAIGYYLKE | KKCFPKGVDM | MAALDLYFQL | 
    400:
    CSVEVTCESG | SVMAATLANG | GICPITGESV | LSAEAVRNTL | SLMHSCGMYD | 
    450:
    FSGQFAFHVG | LPAKSAVSGA | ILLVVPNVMG | MMCLSPPLDK | LGNSHRGTSF | 
    500:
    CQKLVSLFNF | HNYDNLRHCA | RKLDPRREGA | EIRNKTVVNL | LFAAYSGDVS | 
    550:
    ALRRFALSAM | DMEQKDYDSR | TALHVAAAEG | HIEVVKFLIE | ACKVNPFAKD | 
    600:
    RWGNIPLDDA | VQFNHLEVVK | LLQDYQDSYT | LSETQAEAAA | EALSKENLES | 
    602:
    MV
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    MIM:
    SMR:
    UniGene:
    Pfam:
    KEGG:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Human GLS
    Cat.:
    E13728h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human GLS
    Cat.:
    E13728r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Human GLS
    Cat.:
    E13728m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human GLS
    Cat.:
    U13728h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human GLS
    Cat.:
    U13728m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human GLS
    Cat.:
    U13728r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human GLS
    Cat.:
    P13728Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human GLS
    Cat.:
    P13728Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human GLS
    Cat.:
    P13728Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human GLS
    Monoclonal Antibody for Human GLS
    Monoclonal Antibody for Human GLS
    Protein for Human GLS
    Protein for Human GLS
    Protein for Human GLS

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    Linearity
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    References
    1. 1.
      "Molecular cloning, sequencing and expression studies of the human breast cancer cell glutaminase."
      Gomez-Fabre P.M. , Aledo J.C. , del Castillo-Olivares A. , Alonso F.J. , Nunez de Castro I. , Campos J.A. , Marquez J.
      Biochem. J.345:365-375(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);TISSUE SPECIFICITY
      tissue: Brain.
      tissue: Mammary cancer.
    2. 2.
      "Genomic organization and transcriptional analysis of the human l-glutaminase gene."
      Perez-Gomez C. , Mates J.M. , Gomez-Fabre P.M. , del Castillo-Olivares A. , Alonso F.J. , Marquez J.
      Biochem. J.370:771-784(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
      tissue: Brain.
      tissue: Mammary cancer.
    3. 3.
      "Identification and expression of human renal and hepatic glutaminase isoforms."
      Chavez R.A. , Wang C. , Cong R. , Hawkinson J.E. , Forsayeth J.R.
      Submitted (2000-01) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANT PRO-581
      tissue: Brain.
    4. 4.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
      tissue: Liver.
    5. 5.
      "The finished DNA sequence of human chromosome 12."
      Scherer S.E. , Muzny D.M. , Buhay C.J. , Chen R. , Cree A. , Ding Y. , Dugan-Rocha S. , Gill R. , Gunaratne P. , Harris R.A. , Hawes A.C. , Hernandez J. , Hodgson A.V. , Hume J. , Jackson A. , Khan Z.M. , Kovar-Smith C. , Lewis L.R. , more...
      Nature440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    6. 6.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    7. 7.
      "The C-terminus of human glutaminase L mediates association with PDZ domain-containing proteins."
      Olalla L. , Aledo J.C. , Bannenberg G. , Marquez J.
      FEBS Lett.488:116-122(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SNTA1 AND TAX1BP3
    8. 8.
      "Glutaminase 2, a novel p53 target gene regulating energy metabolism and antioxidant function."
      Hu W. , Zhang C. , Wu R. , Sun Y. , Levine A. , Feng Z.
      Proc. Natl. Acad. Sci. U.S.A.107:7455-7460(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;TISSUE SPECIFICITY;INDUCTION
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