Protein name:
Glutaminase liver isoform, mitochondrial (GLS) ;
Alternative:
L-glutamine amidohydrolase ;L-glutaminase ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Interacts with the PDZ domain of the syntrophin SNTA1. Interacts with the PDZ domain of TAX1BP3.
Function:
Plays an important role in the regulation of glutamine catabolism. Promotes mitochondrial respiration and increases ATP generation in cells by catalyzing the synthesis of glutamate and alpha-ketoglutarate. Increases cellular anti-oxidant function via NADH and glutathione production. May play a role in preventing tumor proliferation.
Subcellular Location:
Mitochondrion
Protein Attributes:
50:
MRSMKALQKA | LSRAGSHCGR | GGWGHPSRSP | LLGGGVRHHL | SEAAAQGRET |
100:
PHSHQPQHQD | HDSSESGMLS | RLGDLLFYTI | AEGQERIPIH | KFTTALKATG |
150:
LQTSDPRLRD | CMSEMHRVVQ | ESSSGGLLDR | DLFRKCVSSN | IVLLTQAFRK |
200:
KFVIPDFEEF | TGHVDRIFED | VKELTGGKVA | AYIPQLAKSN | PDLWGVSLCT |
250:
VDGQRHSVGH | TKIPFCLQSC | VKPLTYAISI | STLGTDYVHK | FVGKEPSGLR |
300:
YNKLSLNEEG | IPHNPMVNAG | AIVVSSLIKM | DCNKAEKFDF | VLQYLNKMAG |
350:
NEYMGFSNAT | FQSEKETGDR | NYAIGYYLKE | KKCFPKGVDM | MAALDLYFQL |
400:
CSVEVTCESG | SVMAATLANG | GICPITGESV | LSAEAVRNTL | SLMHSCGMYD |
450:
FSGQFAFHVG | LPAKSAVSGA | ILLVVPNVMG | MMCLSPPLDK | LGNSHRGTSF |
500:
CQKLVSLFNF | HNYDNLRHCA | RKLDPRREGA | EIRNKTVVNL | LFAAYSGDVS |
550:
ALRRFALSAM | DMEQKDYDSR | TALHVAAAEG | HIEVVKFLIE | ACKVNPFAKD |
600:
RWGNIPLDDA | VQFNHLEVVK | LLQDYQDSYT | LSETQAEAAA | EALSKENLES |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Rat
Mouse
Polyclonal Antibody for Human GLS
Polyclonal Antibody for Human GLS
Polyclonal Antibody for Human GLS
Monoclonal Antibody for Human GLS
Monoclonal Antibody for Human GLS
Monoclonal Antibody for Human GLS
R&D Technical Data
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Precision
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Recovery
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Linearity
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);TISSUE SPECIFICITY
tissue :
Brain .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA]
tissue :
Brain .
tissue :
Mammary cancer .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANT PRO-581
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
tissue :
Liver .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
6.
Mural R.J.
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Submitted (2005-07) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH SNTA1 AND TAX1BP3
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;SUBCELLULAR LOCATION;TISSUE SPECIFICITY;INDUCTION